Thermo Fisher Scientific ZBTB5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• The recommended shelf life for this product is 1 year from date of receipt.

Target Information

The ZBTB family of proteins consists of diverse zinc finger proteins that contain a BTB (BR-C, ttk, and bab) domain. ZBTB5 was identified through sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. It binds DNA and represses transcription of the cell cycle arrest gene p21. ZBTB5 interacts with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, leading to deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. This activity promotes cell proliferation and progression, suggesting ZBTB5 may act as a proto-oncogene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.