Thermo Fisher Scientific ZBTB5 Polyclonal Antibody

Thermo Fisher Scientific ZBTB5 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution

• 1:1,000

Publications

• [References not provided]

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

The ZBTB family of proteins comprises diverse zinc finger proteins that also contain a BTB (BR-C, ttk, and bab) domain.
ZBTB5 was identified through sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein.
It binds DNA and can directly repress transcription of the cell cycle arrest gene p21.
ZBTB5 interacts with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter.
ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.