Thermo Fisher Scientific BUBR1 Polyclonal Antibody
BUBR1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. Human에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 분열 체크포인트 연구 및 암 관련 단백질 분석에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 274–525 of Human BUB1 beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546752 |
Product Specific Information
- Recommended positive controls: 293T, HeLa, HepG2, K562
- Predicted reactivity: Bovine (87%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
BUBR1 is a member of the Ser/Thr protein kinase family and a component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. Compromised spindle checkpoints are thought to contribute to genetic instability and malignant transformation. Human cells contain two related checkpoint protein kinases derived from the BUB1 gene: hBUBR1 and hBUB1. Both monitor mitotic kinetochore–microtubule interactions, and hBUBR1 is essential for preventing premature anaphase entry. BUBR1 has been detected in various human cancers and identified as a binding partner of BCSG1, which may accelerate breast cancer progression by compromising mitotic checkpoint control.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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