Thermo Fisher Scientific TNFRSF14 Polyclonal Antibody
Human TNFRSF14(HVEM)을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), Flow Cytometry에 사용 가능. KLH 결합 합성 펩타이드(aa 210-236)를 면역원으로 제작. Protein A 및 항원 친화 크로마토그래피로 정제되었으며, 0.25 mg/mL 농도의 액상 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 210–236 from the central region of human TNFRSF14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543603 |
Target Information
TNFRSF14 is a member of the TNF-receptor superfamily and acts as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV envelope glycoprotein D (gD) to TNFRSF14 facilitates viral entry. The cytoplasmic region interacts with TRAF family members, mediating signal transduction pathways that activate immune responses. Activation of TNFRSF14 in T cells promotes proliferation and cytokine production, contributing to inflammation and enhanced CTL-mediated tumor immunity. Multiple alternatively spliced transcript variants have been reported, though some full-length sequences remain undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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