Thermo Fisher Scientific Beta-Arrestin 2 Polyclonal Antibody
Beta-Arrestin 2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 고순도 제품으로, 4°C에서 보관하며 연구용으로 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 310 and 360 of human Arrestin, Beta 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
Beta-arrestin-2 (ARRB2) is an adaptor protein of the arrestin family containing N- and C-arrestin domains. It plays a regulatory role in heterotrimeric G protein-coupled receptor desensitization and modulates beta2-adrenergic receptor (β2AR) function by enhancing β2AR-mediated nuclear translocation of ERK. ARRB2 binds phosphorylated β2ARs, reducing their ability to activate G(S) proteins. Together with AIP4, ARRB2 mediates endosomal sorting of CXCR4 into a degradative pathway and may participate in hormone-specific desensitization of TSH receptors. It is also a Ca²⁺-binding protein in retinal outer segments, interacting with P-rhodopsin and contributing to synaptic transmission in photoreceptor cells. ARRB2 is widely expressed, particularly in neuronal tissues and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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