Thermo Fisher Scientific Prosapip2 Polyclonal Antibody
Prosapip2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 바이러스 감염 신호전달 연구 및 TNF/NF-kB 경로 분석에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 300–350 of human SINTBAD/TBKBP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540748 |
Target Information
Prosapip2 (TBKBP1) is essential for signal transduction during viral infection and plays a major role in the TNF/NF-kappa-B pathway. It acts as an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE, contributing to antiviral innate immunity.
Prosapip2 is a 615-amino-acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains linked by interchain disulfide bonds. It shows ubiquitous expression, with the highest levels in ovary and neuronal tissues.
It binds TBK1 to activate IRF3, which regulates antiviral gene expression. Recent studies indicate Prosapip2 interacts with ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between the postsynaptic density and the cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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