Thermo Fisher Scientific Phospho-c-Myc (Ser62) Polyclonal Antibody
Phospho-c-Myc (Ser62) 폴리클로날 항체로 인간, 마우스, 랫트 시료에 반응합니다. 세포 증식 및 종양 관련 연구에 적합하며, ICC/IF에 1:100–1:200 희석으로 사용 가능합니다. 액상 형태로 -20°C 보관하며, Western blot 및 세포면역염색에 권장됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:200
- Suggested positive control: HeLa cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of serine 62 (P-L-S(p)-P-S) derived from Human Myc |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2554260 |
Product Specific Information
- Recommended positive control for Western blot: K562 cells
- Recommended positive control for ICC/IF: HeLa cells
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a critical role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with regulation of cell proliferation and cycle control.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression can induce apoptosis and contribute to tumorigenesis in multiple tissues, including lung, breast, colon, and others.
Amplification or translocation of the c-Myc gene is implicated in several cancers, including Burkitt’s lymphoma and other B-cell lymphoproliferative disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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