Thermo Fisher Scientific Bcr Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal Bcr 항체로 다양한 면역실험(IHC, ICC, Flow, ELISA)에 사용 가능. KLH 결합 합성 펩타이드 항원 기반, Protein A 정제, 고순도 액상 형태. 연구용으로만 사용.
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- pk
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Thermo Fisher Scientific Bcr Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Bcr, amino acids 1201–1271 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, commonly found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint occurs within the BCR gene, resulting in a fusion protein encoded by sequences from both BCR and ABL (chromosome 9). While the BCR-ABL fusion protein is well studied, the normal BCR protein’s function remains unclear. It exhibits serine/threonine kinase activity and acts as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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