Thermo Fisher Scientific CCL4 Monoclonal Antibody (46907)
마우스 CCL4/MIP-1β를 인식하는 Rat IgG2a 단일클론 항체로, 중화(Neutralization) 실험에 적합합니다. Lyophilized 형태로 제공되며, PBS + 5% trehalose buffer에 보관합니다. 단백질 A/G로 정제되어 높은 순도를 보장하며, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CCL4 Monoclonal Antibody (Clone 46907)
Applications
- Neutralization (Neu)
Tested Dilution: 1–3 µg/mL
Publications: [References available upon request]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 46907 |
| Immunogen | E. coli-derived recombinant mouse CCL4/MIP-1β (Ala24–Asn92) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609426 |
Product Specific Information
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of antibody (LAL method).
Target Information
CCL4 (macrophage inflammatory protein 1-beta, MIP-1β) belongs to the chemokine CC family. It plays a role in chemotaxis, inflammation, and immune homeostasis.
CCL4 is produced by macrophages, lymphocytes, and dendritic cells in response to bacterial endotoxins. It recruits various inflammatory cells to infection sites and regulates their activation states.
Both CCL4 and CCL3 are involved in host defense against pathogens by guiding immune cell trafficking. While both affect monocytes similarly, CCL4 preferentially attracts CD4+ lymphocytes, whereas CCL3 attracts CD8+ lymphocytes.
CCL4 also acts as a chemoattractant for B cells, eosinophils, and dendritic cells. Its processed form can downregulate CCR5 receptor expression, inhibiting CCR5-mediated HIV-1 entry into T cells.
CCL4 binds with high affinity to CCR5 receptors.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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