Thermo Fisher Scientific PNAS4 Polyclonal Antibody
PNAS4 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫트 반응성. Western blot 등 연구용에 적합하며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며 냉장 또는 냉동 보관 가능.
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Thermo Fisher Scientific PNAS4 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide near the carboxy terminus of human PNAS4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154835 |
Product Specific Information
- Suggested positive control: EL4 cell lysate
- PA5-20763 can be used with blocking peptide PEP-0877
Target Information
PNAS4 is a highly conserved protein with strong homology across species from plants to animals. It was first identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4.
PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in tumor cells such as U2OS, SKOV3, and A549.
Mechanisms of action:
- Overexpression of PNAS4 causes S phase arrest by regulating cell cycle-related proteins.
- PNAS4 induces apoptosis through the mitochondrial apoptosis pathway.
Recent evidence suggests PNAS4 may be involved in the genesis of certain cancers and could be a potential candidate for lung cancer therapy, alone or in combination with gemcitabine.
At least two isoforms of PNAS4 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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