Thermo Fisher Scientific Phospho-RIP2 (Ser531) Polyclonal Antibody
RIPK2 단백질의 Ser531 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P)에서 검증됨. Human, Mouse, Rat 반응성. 1 mg/mL 농도의 액상 형태로, PBS(50% glycerol) 보존. -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RIPK2 (Accession O43353), corresponding to amino acid residues around phosphorylated Ser531. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816820 |
Product Specific Information
This antibody detects endogenous levels of RIPK2 only when phosphorylated at Ser531.
Target Information
RIPK2 is a serine/threonine kinase involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize, and recruit RIPK2 through CARD-CARD domains. RIPK2 contributes to tyrosine phosphorylation of ARHGEF2 through Src kinase, leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes Lys-63-linked polyubiquitination by E3 ligases XIAP, BIRC2, and BIRC3. The polyubiquitinated RIPK2 mediates recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing further Lys-63-linked polyubiquitination and activation of IKBKB/IKKB. Consequently, NF-kappaB is released, translocates to the nucleus, and activates transcription of genes involved in immune response, growth control, and apoptosis protection. RIPK2 also plays a role during T-cell receptor engagement by promoting BCL10 phosphorylation and subsequent NF-kappaB activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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