Thermo Fisher Scientific TIA1 (T-Cell-Restricted Intracellular Antigen-1) Monoclonal Antibody (rTIA1/1353)

Applications

• Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL

Product Specifications

Target Information

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through signals from:

1. WNT protein (WNT3A) to stabilize beta-catenin
2. Noggin, a bone morphogenetic protein inhibitor

Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.