Thermo Fisher Scientific DIO3 Polyclonal Antibody
Rabbit polyclonal antibody against human DIO3 protein. Validated for Western blot in human, mouse, and rat samples. Supplied as liquid in PBS with 50% glycerol. For research use only.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human DIO3 (UniProt ID: P55073-1, amino acids 117–141) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691987 |
Product Specific Information
Predicted to react with human, mouse, and rat samples.
Target Information
DIO3 belongs to the iodothyronine deiodinase family and catalyzes the inactivation of thyroid hormones by inner ring deiodination of thyroxine (T4) and triiodothyronine (T3) to inactive metabolites (RT3 and T2). This enzyme is highly expressed in the pregnant uterus, placenta, fetal, and neonatal tissues, suggesting an essential role in thyroid hormone regulation during embryological development.
The protein contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3′ UTR of Sec-containing genes includes a SECIS element required for recognition of UGA as a Sec codon.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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