Thermo Fisher Scientific DIO3 Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:3,000

Product Specifications

Product Specific Information

Predicted to react with human, mouse, and rat samples.

Target Information

DIO3 belongs to the iodothyronine deiodinase family and catalyzes the inactivation of thyroid hormones by inner ring deiodination of thyroxine (T4) and triiodothyronine (T3) to inactive metabolites (RT3 and T2). This enzyme is highly expressed in the pregnant uterus, placenta, fetal, and neonatal tissues, suggesting an essential role in thyroid hormone regulation during embryological development.
The protein contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3′ UTR of Sec-containing genes includes a SECIS element required for recognition of UGA as a Sec codon.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.