Thermo Fisher Scientific AZIN1 Monoclonal Antibody (OTI1D12), TrueMAB
AZIN1 단백질을 인식하는 Mouse IgG1 단클론 항체로, 인간·마우스·랫트 시료에 반응. Western blot에 최적화되어 있으며, carrier-free 형태로 재결합 및 결합 실험에 적합. -20°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D12 |
| Immunogen | Human recombinant protein fragment (AA 260–448 of human AZIN1, produced in E. coli) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Antizyme inhibitor (AZIN1) is a protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake.
AZI, an enzymatically inactive ODC homolog, counteracts the inhibitory effects of ODC antizymes (OAZ1, OAZ2, OAZ3) by competing for antizyme binding.
This interaction prevents antizyme-dependent ODC degradation and releases ODC monomers from inactive complexes, leading to formation of catalytically active ODC homodimers and restoration of polyamine production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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