Thermo Fisher Scientific CHRNA7 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.5–1 µg/mL

Product Specifications

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.

CHRNA7 (Also known as Nicotinic Acetylcholine Receptor alpha 7) is a major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses.

CHRNA7 has a signal peptide, followed by an N-terminal extracellular domain, three membrane-spanning regions, an intracellular domain, a fourth transmembrane region, and an extracellular C-terminal tail.

The nicotinic acetylcholine receptor alpha-7 subunit is required for acetylcholine inhibition of macrophage TNF release and is essential for inhibiting cytokine synthesis via the cholinergic anti-inflammatory pathway. Upregulation of CHRNA7 receptors may serve as a compensatory response to maintain basocortical cholinergic activity during disease progression or may interact with beta-amyloid in disease pathogenesis.

GenScript Rabbit Anti-CHRNA7 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from the N-terminal extracellular domain of human CHRNA7 (Swiss Prot: P36544).

Target Information

Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChR alpha7, is encoded by the CHRFAM7A gene located on a region of chromosome 15 associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder.

CHRFAM7A (also known as D-10 or CHRNA7) is a 412 amino acid multi-pass membrane protein belonging to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, which mediate synaptic signal transmission. CHRFAM7A is expressed in the hippocampus, and alternative splicing of the CHRFAM7A gene produces two splice variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.