Thermo Fisher Scientific ERAS Monoclonal Antibody (OTI2C6), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The human ERAS gene, initially reported as a processed pseudogene (HRasp, Ha-Ras2), was later identified as potentially encoding a functional ERAS protein.
ERAS supports tumorigenic growth in embryonic stem cells by producing a constitutively active Ras protein. Although ERAS shares less than 50% amino acid identity with H-Ras, key Ras functional domains are conserved. The protein includes residues identical to active Ras mutants and induces oncogenic transformation in NIH 3T3 cells.
The human ERAS gene is localized on chromosome Xp11.23.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.