
Thermo Fisher Scientific ERAS Monoclonal Antibody (OTI2C6), TrueMAB
ERAS 단백질을 인식하는 Mouse monoclonal antibody로 Western blot과 Immunocytochemistry에 적합. Human 시료 반응성, Lyophilized 형태로 제공되며, 재구성 후 약 1 mg/mL 농도. 연구용으로 종양 관련 Ras 단백질 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C6 |
| Immunogen | Full length human recombinant protein of human ERAS produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The human ERAS gene, initially reported as a processed pseudogene (HRasp, Ha-Ras2), was later identified as potentially encoding a functional ERAS protein.
ERAS supports tumorigenic growth in embryonic stem cells by producing a constitutively active Ras protein. Although ERAS shares less than 50% amino acid identity with H-Ras, key Ras functional domains are conserved. The protein includes residues identical to active Ras mutants and induces oncogenic transformation in NIH 3T3 cells.
The human ERAS gene is localized on chromosome Xp11.23.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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