Thermo Fisher Scientific BMPR2 Polyclonal Antibody
BMPR2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. 인간 및 설치류 등 여러 종에 반응하며, 고순도 친화 크로마토그래피 정제 제품. 연구용으로만 사용.
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Thermo Fisher Scientific BMPR2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human BMPR2 (Accession Q13873), corresponding to amino acid residues I734–V784 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818398 |
Product Specific Information
Antibody detects endogenous levels of total BMPR2.
Target Information
BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs involved in endochondral bone formation and embryogenesis. Loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH). BMPR2 also plays an essential role in human T-cell differentiation. BMPs transduce signals through heteromeric complexes of type I and type II serine/threonine kinase receptors. Mutations in BMPR2 have been associated with primary pulmonary hypertension and pulmonary venoocclusive disease.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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