Thermo Fisher Scientific BRF1 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Mouse, Rat, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Chinese hamster

Target Information

RNA polymerase (Pol) III synthesizes tRNA, 5S rRNA, 7SL RNA, and U6 snRNA, and is overexpressed in many transformed cell lines and tumors. To maintain rapid growth, cells must produce high levels of Pol III–transcribed RNA, requiring TFIIIB and TFIIIC2 transcription factor complexes.
TFIIIC2 consists of TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, and TFIIIC63, which are overexpressed in malignant cells such as ovarian carcinomas. TFIIIC2 recruits RNA Pol III and TFIIIB to promoter elements and may play a key role in deregulation of cancer cells.
TFIIIB includes TBP, TFIIB-related factor 1 (TFIIIB90, BRF1), and TFIIIB, all upregulated in transformed cells. In many carcinomas, tumor suppressors RB and p53 are inactivated, impairing their ability to bind and inactivate TFIIIB.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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