Thermo Fisher Scientific CIP2A Polyclonal Antibody
CIP2A 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, IHC 및 IHC(Paraffin) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:500
- References: -
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
- References: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 and 600 of human cancerous inhibitor of PP2A (CIP2A, UniProt ID: Q8TCG1-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Inhibition of protein phosphatase 2A (PP2A) activity is a prerequisite for human cell transformation. Cancerous Inhibitor of PP2A (CIP2A) interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and prevents c-Myc proteolytic degradation.
CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. Overexpression of CIP2A leads to transformation of human cells and is observed in head and neck squamous cell carcinoma (HNSCC) and colon cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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