Thermo Fisher Scientific C10orf54 Monoclonal Antibody (UMAB271), UltraMAB
인간 C10orf54(VISTA)을 인식하는 UMAB271 클론 단일클론 항체로, IHC 및 ChIP 분석에 적합합니다. 고순도 친화 크로마토그래피로 정제되었으며 PBS/BSA/glycerol 용액 형태로 제공됩니다. 암 면역치료 연구에 활용 가능한 고품질 연구용 항체입니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50
ChIP assay (ChIP)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB271 |
| Immunogen | Full length human recombinant protein of human C10ORF54 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1, it has a distinct expression pattern.
In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells, with highest densities on myeloid cells and lower levels on T cells. It is typically absent on B cells.
VISTA expressed by antigen-presenting cells directly suppresses proliferation and cytokine production of CD4 and CD8 T cells, making it a potential target for cancer immunotherapy.
Reported ligands of VISTA include CD28H, VSIG-3, and VSIG-8.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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