Thermo Fisher Scientific NMT2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Bovine.

Target Information

Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most proteins in the eukaryotic cytosol and nucleus, while others are processed via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is a multisubunit, ATP-dependent complex (~2.5 MDa) composed of a 20S core and 19S regulatory subunits. The 19S units recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S lumen.
Defects in this pathway are associated with genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.