Thermo Fisher Scientific Human ALK, GST Tag Recombinant Protein

Thermo Fisher Scientific Human ALK, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use. Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted. For larger sizes, prepare aliquots to reduce freeze/thaw cycles (aliquots below 20 µL not recommended). Never store kinase diluted. Properly stored at -80°C, product is guaranteed for 6 months from purchase date.

Related Links:

• Learn more about our kinase proteins
• LanthaScreen™ Kinase Activity Assay
• LanthaScreen™ Eu Kinase Binding Assay

Target Information

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development. Mutations, rearrangements, and amplifications in the ALK gene are associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangement typically fuses the ALK gene (chromosome 2) with the nucleophosmin gene (chromosome 5), forming the oncogenic NPM-ALK fusion gene. ALK possesses a transmembrane and extracellular domain, absent in the NPM-ALK product, and shows high similarity to LTK. It plays a critical role in neuronal development and signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.