Thermo Fisher Scientific Laminin, gamma 1 (LAMC1) Monoclonal Antibody (SPM193)
Laminin γ1(LAMC1)을 인식하는 Rat monoclonal antibody(SPM193). IHC, ICC/IF, Flow Cytometry에 사용 가능. Human, Mouse 반응성. Protein A/G 정제, PBS buffer, 무보존제. 연구용으로 세포외기질 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM193 |
| Immunogen | Murine EHS laminin preparation |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Laminins are essential and abundant structural non-collagenous glycoproteins localized to basement membranes. These membranes are composed of Laminins stabilized by Type IV Collagen networks, Nidogen, and various proteoglycans. They are found under epithelial layers, around blood vessel endothelium, and surrounding muscle, peripheral nerve, and fat cells.
Basement membrane formation influences cell proliferation, phenotype, migration, gene expression, and tissue architecture. Each Laminin is a heterotrimer consisting of alpha, beta, and gamma chain subunits that are secreted and incorporated into the extracellular matrix (ECM). Laminins can self-assemble, bind to other matrix macromolecules, and interact with cells via Integrins, dystroglycan, and Laminin receptors.
The human Laminin gamma-1 gene (LAMC1) is located on chromosome 1q31 and is ubiquitously expressed in tissues producing basement membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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