Thermo Fisher Scientific Megsin Polyclonal Antibody
Megsin 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Megsin, amino acids 301–380 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Megsin (also known as SerpinB7 or TP55) is a 380 amino acid cytoplasmic protein predominantly expressed in mesangial cells, which are essential for maintaining glomerular structure and function. As a member of the serpin family, Megsin acts as a serine protease inhibitor that can inactivate MMP-2, MMP-9, and plasmin—key enzymes involved in extracellular matrix degradation. Overexpression of Megsin leads to mesangial cell proliferation and matrix expansion, often associated with immune complex deposition. These characteristics suggest Megsin plays a significant role in renal structure regulation and may be implicated in various nephropathies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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