Thermo Fisher Scientific TIRAP Recombinant Rabbit Monoclonal Antibody (ARC1686)
TIRAP 단백질을 타겟으로 하는 재조합 토끼 단클론 항체로, WB, IHC, ELISA 등 다양한 응용에 적합. 인간, 생쥐, 랫트 반응성. HEK293 발현, 액상 형태, 고순도 친화성 정제. 연구용으로만 사용.
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Thermo Fisher Scientific TIRAP Recombinant Rabbit Monoclonal Antibody (ARC1686)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1686 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human TIRAP (P58753) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.02 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898113 |
Product Specific Information
- Positive Samples: 293T, HepG2, THP-1, Mouse brain, Rat spleen, Rat thymus
- Immunogen sequence:
MASSTSLPAP GSRPKKPLGK MADWFRQTLL KKPKKRPNSP ESTSSDASQP TSQDSPLPPS LSSVTSPSLP PTHASDSGSS RWSKDYDVCV CHSEEDLVAA
Target Information
Toll-like receptors (TLRs) are signaling molecules that recognize microbial products during infection and serve as an important link between innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors.
In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is abolished, indicating that MyD88 and TIRAP work together and are both required for TLR2 signaling. These mice are also resistant to LPS toxicity and show defects in NF-κB and MAP kinase activation, suggesting TIRAP involvement in TLR4 signaling.
Important Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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