Thermo Fisher Scientific CD74 (B-Cell Marker) Monoclonal Antibody (LN-2, CLIP/813)
CD74(B-Cell Marker) 단클론 항체로 인간 시료에 반응하며 IHC, ICC/IF, Flow Cytometry 등에 사용 가능. LN-2 및 CLIP/813 클론 기반, Protein A/G 정제, 액상 형태로 제공. 4°C 보관, 연구용 전용 시약.
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Thermo Fisher Scientific CD74 (B-Cell Marker) Monoclonal Antibody (LN-2, CLIP/813)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LN-2, CLIP/813 |
| Immunogen | SU-DHL-4 lymphoma cells (LN-2); Recombinant full-length human CD74 protein (CLIP/813) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, with DRB1 containing polymorphisms that define peptide binding specificity. HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
These MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells, playing a critical role in initiating immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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