Thermo Fisher Scientific CD74 (B-Cell Marker) Monoclonal Antibody (LN-2, CLIP/813)

Thermo Fisher Scientific CD74 (B-Cell Marker) Monoclonal Antibody (LN-2, CLIP/813)

Applications and Tested Dilution

Product Specifications

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, with DRB1 containing polymorphisms that define peptide binding specificity. HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
These MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells, playing a critical role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.