Thermo Fisher Scientific CD74 (B-Cell Marker) Monoclonal Antibody (CLIP/1133)
인간 CD74 단백질을 인식하는 마우스 단클론 항체로, B세포 마커 연구에 적합합니다. Western blot에 최적화되어 있으며, 단백질 A/G로 정제된 액상 형태입니다. PBS(pH 7.4) 버퍼에 보존제 없이 제공되며, -20°C에서 보관합니다.
- 카탈로그번호
- 972-MSM4-P1ABX
- 판매단위
- pk
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Applications
- Western Blot (WB): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CLIP/1133 |
| Immunogen | Recombinant full-length human CD74 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The DRA gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, while the beta chain contains polymorphisms determining peptide binding specificities.
HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
The human MHC class II molecules (DR, DQ, DP) bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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