Thermo Fisher Scientific CHOP Polyclonal Antibody
Rabbit polyclonal antibody targeting human CHOP (DDIT3) for Western blot applications. Detects cytoplasmic and nuclear CHOP under ER stress conditions. Supplied as liquid form, 0.89 mg/mL concentration, stored at -20°C. For research use only.
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- PA587512
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–100 of human DDIT3/CHOP (NP_0040742) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.89 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804213 |
Product Specific Information
Immunogen sequence:
MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG
Positive Samples: Mouse testis, Mouse brain
Cellular Location: Cytoplasm, Nucleus
Target Information
GADD153 (also known as CHOP or DDIT3) is a small nuclear protein that dimerizes with transcription factors C/EBP alpha and beta. The resulting complex inhibits normal C/EBP binding and promotes binding to stress-related non-classical C/EBP targets. Under normal conditions, CHOP expression is minimal, but it is strongly upregulated under cellular or ER stress, such as tunicamycin treatment, nutrient deprivation, or disruption of calcium flux across the ER membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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