Thermo Fisher Scientific CDK9 Polyclonal Antibody
CDK9 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성 보유. 고순도 Affinity Chromatography 정제, 안정적인 PBS/glycerol 저장용액. 연구용으로만 사용 가능합니다.
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- PA587517
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 153–372 of human CDK9 (NP_0012521) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.6 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804217 |
Product Specific Information
Immunogen sequence:
ANVLITRDGV LKLADFGLAR AFSLAKNSQP NRYTNRVVTL WYRPPELLLG ERDYGPPIDL WGAGCIMAEM WTRSPIMQGN TEQHQLALIS QLCGSITPEV WPNVDNYELY EKLELVKGQK RKVKDRLKAY VRDPYALDLI DKLLVLDPAQ RIDSDDALNH DFFWSDPMPS DLKGMLSTHL TSMFEYLAPP RRKGSQITQQ STNQSRNPAT TNQTEFERVF
Positive Samples: LO2, HeLa, A-549, SKOV3, Mouse brain, Rat testis
Cellular Location: Cytoplasm, Nucleus, PML body
Target Information
CDK9 is a serine/threonine kinase that forms an active holoenzyme complex with CyclinT1, playing a key role in regulating the eukaryotic cell cycle. It regulates cytokine-inducible transcription networks and promotes RNA synthesis for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also phosphorylates the CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 may lead to cardiac hypertrophy and heart failure.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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