Thermo Fisher Scientific Phospho-Caspase 8 (Ser347) Polyclonal Antibody
Phospho-Caspase 8 (Ser347) rabbit polyclonal antibody로 인간 및 마우스 시료에서 사용 가능. Western blot과 IHC(P) 적용. 항원 친화 크로마토그래피로 정제된 고순도 제품. 세포 사멸 신호 전달 연구에 적합.
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- PA536709
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Caspase-8 around the phosphorylation site of Serine 347 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553672 |
Product Specific Information
This antibody detects endogenous protein at molecular weights of 38 and 55 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family, playing a central role in the execution phase of apoptosis. It exists as an inactive proenzyme that is activated through proteolytic processing to form a heterodimeric enzyme. Caspase 8 interacts with FADD and is involved in Fas-mediated cell death. It has been linked to neurodegenerative diseases such as Huntington’s disease. Overexpression induces apoptosis, which can be blocked by ICE family inhibitors. Multiple spliced transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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