Thermo Fisher Scientific CD27 Polyclonal Antibody
Thermo Fisher Scientific의 CD27 폴리클로날 항체는 Mouse 시료에 반응하며, Western Blot과 ELISA에 적합합니다. 재조합 CD27 단백질을 면역원으로 사용하였으며, 액상 형태로 제공됩니다. 연구용으로 세포 증식 및 사멸 관련 TNF 수용체 연구에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–191 of human CD27 (NP_0012331) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.92 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901265 |
Product Specific Information
- Positive Samples: Mouse lung
- Immunogen sequence:
ATPAPKSCPE RHYWAQGKLC CQMCEPGTFL VKDCDQHRKA AQCDPCIPGV SFSPDHHTRP HCESCRHCNS GLLVRNCTIT ANAECACRNG WQCRDKECTE CDPLPNPSLT ARSSQALSPH PQPTHLPYVS EMLEARTAGH MQTLADFRQL PARTLSTHWP PQRSLCSSDF IR
Target Information
CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. Members of this superfamily regulate cell proliferation and death.
CD27 and its ligand CD70 are predominantly expressed in lymphocytes. CD27 expression increases upon antigen receptor ligation, while CD70 requires co-stimulatory or pro-inflammatory signals.
CD27 forms disulfide-linked homodimers on mature thymocytes, peripheral blood T cells, and a subset of B cells. Activation of T cells via the TCR-CD3 complex upregulates CD27 and releases its soluble form (sCD27), a prognostic marker for B cell malignancies.
CD27-binding protein (SIVA) is a proapoptotic protein interacting with CD27, playing a role in apoptosis. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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