Thermo Fisher Scientific Mouse NCoR1 (aa 2437-2453) Synthetic Peptide

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

-

Product Specifications

Class

Synthetic

Type

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

PEP-061 is an 18 amino acid synthetic peptide whose sequence corresponds to residues 2437-2453 of the mouse N-CoR protein with an N-terminal cysteine added for immunogen preparation. The sequence of this peptide is (amino to carboxy terminus): C-P2437-A-P-L-L-S-A-Q-Y-E-T-L-S-D-S-D-D2453

This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and N-CoR, catalog # PA1-844A. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.

Reconstitute with 0.1 mL of distilled water.

Target Information

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.