Thermo Fisher Scientific PON1 Monoclonal Antibody (4G8D3)
Thermo Fisher Scientific의 PON1 단클론 항체(4G8D3)는 인간 PON1 단백질을 인식하며, Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. 고순도 액상 항체로, 안정적인 신호 검출과 재현성이 우수합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:200–1:400 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G8D3 |
| Immunogen | Partial recombinant human PON1 (residues 1–200) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS with 0.5% proprietary stabilizer |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4 °C short term; for long-term storage, store at −20 °C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2717273 |
Target Information
The paraoxonase (PON) gene family in humans includes PON1, PON2, and PON3, located adjacently on chromosome 7q21.3–22.1.
PON1 is primarily synthesized in the liver and secreted into plasma, where it associates with high-density lipoproteins (HDL).
It hydrolyzes active metabolites of organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon) and nerve agents such as sarin, soman, and VX.
PON1 polymorphisms are implicated in neurodegeneration and may be an independent risk factor for Parkinson’s disease.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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