Thermo Fisher Scientific FOLH1 Monoclonal Antibody (UMAB27), UltraMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The FOLH1 gene encodes a type II transmembrane glycoprotein of the M28 peptidase family. This protein acts as a glutamate carboxypeptidase on substrates such as folate and N-acetyl-L-aspartyl-L-glutamate. It is expressed in prostate, central and peripheral nervous systems, and kidney.
Mutations in this gene may impair intestinal folate absorption, leading to low blood folate levels and hyperhomocysteinemia. Expression in the brain is linked to glutamate excitotoxicity-related conditions. In the prostate, FOLH1 is upregulated in cancer cells and serves as a diagnostic and prognostic marker for prostate cancer.
This gene likely originated from a chromosomal duplication event and produces multiple isoforms via alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.