Thermo Fisher Scientific Cathepsin A Polyclonal Antibody
Cathepsin A 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 실험에 적합하며, Human과 Mouse 반응성. 고순도 Protein A 및 항원 친화 크로마토그래피 정제, 안정한 액상 형태로 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 18–45 amino acids from the N-terminal region of human CTSA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541478 |
Target Information
The cathepsin family of proteolytic enzymes includes several diverse classes of proteases.
Cathepsins B, L, H, K, S, and O comprise the cysteine protease class.
Cathepsins D and E comprise the aspartyl protease class.
The serine protease class includes cathepsin G.
Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation.
Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with β-galactosidase (β-gal) and α-neuraminidase (Neu1).
Cathepsin A functions to protect β-gal and Neu1 from intralysosomal proteolysis.
Deficiencies in cathepsin A lead to deficiencies in β-gal and Neu1.
The gene encoding human cathepsin A maps to chromosome 20q13.12.
Mutations in this gene cause galactosialidosis, a lysosomal storage disorder resulting from β-gal and Neu1 deficiencies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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