Thermo Fisher Scientific CACNA1C Polyclonal Antibody
Thermo Fisher Scientific의 CACNA1C Polyclonal Antibody는 인간, 생쥐, 랫트에서 반응하며 WB 및 IHC에 사용 가능합니다. 합성 펩타이드 항원을 기반으로 제작된 rabbit IgG 항체로, 고순도 및 높은 특이성을 제공합니다. 연구용으로 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
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Applications
- Western Blot (WB): Tested Dilution 1:1,000
- Immunohistochemistry (IHC): Tested Dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 50–100 of human CACNA1C conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen shares 96% identity with mouse, rat, and rabbit sequence.
- Specificity of this antibody: CACNA1C.
Target Information
CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel.
Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization.
The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell.
The calcium channel complex includes alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio.
Multiple isoforms exist due to alternative splicing or different gene encoding.
The CACNA1C protein binds to and is inhibited by dihydropyridine.
Alternative splicing results in many transcript variants encoding different proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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