Thermo Fisher Scientific AIF Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Immunogen sequence:
  VDSSLPTVGV FAKATAQDNP KSATEQSGTG IRSESETESE ASEITIPPST
• Storage guidance:
  For short-term use, store at 2–8°C up to 1 week.
  For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology:
  Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 79%

Target Information

Apoptosis Inducing Factor (AIF) induces chromatin condensation and DNA fragmentation. It is localized in mitochondria and translocates to the nucleus during apoptosis, promoting release of apoptogenic proteins such as cytochrome c and caspase-9. AIF is highly conserved between human and mouse and widely expressed. Mutations in the AIF gene cause combined oxidative phosphorylation deficiency 6, leading to severe mitochondrial encephalomyopathy. Multiple transcript variants and a pseudogene on chromosome 10 have been identified.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.