Thermo Fisher Scientific DCTN1 Monoclonal Antibody (2E4-1C2)
Human DCTN1 단백질을 인식하는 mouse monoclonal antibody로 Western blot과 ELISA에 적합. Dynactin 1 복합체 연구용으로 사용. 액상 형태, PBS buffer, 보존제 없음. -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E4-1C2 |
| Immunogen | DCTN1 (AAH06163, 1–198 a.a.) full-length recombinant protein with GST tag (GST MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MPGPGLVKDS PLLLQQISAM RLHISQLQHE NSILKGAQMK ASLASLPPLH VAKLSHEGPG SELPAGALYR KTSQLLETLN QLSTHTHVVD ITRTSPAAKS PSAQLMEQVA QLKSLSDTVE KLKDEVLKET VSQRPGATVP TDFATFPSSA FLRAKEEQQD DTVYMGKVTF SCAAGFGQRH RLVLTQEQLH QLHSRLIS
Target Information
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein and plays roles in:
- ER-to-Golgi transport
- Centripetal movement of lysosomes and endosomes
- Spindle formation and chromosome movement
- Nuclear positioning and axonogenesis
The DCTN1 subunit directly interacts with dynein intermediate chain and binds microtubules via its conserved CAP-Gly domain. Alternative splicing produces multiple transcript variants. Mutations cause distal hereditary motor neuronopathy type VIIB (HMN7B), also known as distal spinal and bulbar muscular atrophy (dSBMA).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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