Thermo Fisher Scientific Kidins220 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size.
• Ships as lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and store at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

The Kidins220 gene encodes a transmembrane protein predominantly expressed in the nervous system, where it regulates neuronal survival, differentiation, and synaptic plasticity. This protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, acting as a scaffold mediating crosstalk between the neurotrophin pathway and other intracellular signaling pathways.
Aberrant expression is associated with neuropsychiatric and neurodegenerative diseases such as Alzheimer’s disease. Mutations can cause syndromes characterized by spastic paraplegia, intellectual disability, nystagmus, and obesity.
Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.