Thermo Fisher Scientific IKBKE Monoclonal Antibody (OTI3C5), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended product: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

IKBKE is an activator of nuclear factor-kappa-B (NF-κB). Overexpression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death.
NF-κB is a ubiquitous transcription factor essential for gene expression during immune and inflammatory responses. It mediates expression of various genes in response to extracellular stimuli and is regulated by Ikappa-B proteins in the cytoplasm.
Ikappa-B is phosphorylated by the IKK complex (IKK-α, IKK-β, and IKK-γ). A novel molecule in this complex, IKK-iota/IKK-i, has been identified. IKK epsilon is required for NF-κB activation by PMA and T cell receptors but not by TNF-α or IL-1. IKK-iota/IKK-i expression is inducible by TNF-α, IL-1, and LPS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.