Thermo Fisher Scientific FFA4, FFA4 Receptor Polyclonal Antibody
FFA4 수용체를 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 인간 시료 반응성, 연구용으로 GPCR 관련 신호 연구에 활용 가능.
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Thermo Fisher Scientific FFA4 Receptor Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide presents the carboxyl-terminal tail of human FFA4 (GPR120, UniProt ID: Q5NUL3-2). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
An EST for GPR120 has been isolated from a human colon cancer library. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms. Activating ligands induce conformational changes that lead to signaling via G-proteins and downstream effectors.
Studies have shown multiple mechanisms involved in the negative regulation of GPCRs, which have significant implications for cellular physiology and pharmacological research.
GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) are examples of successful pharmaceuticals in mental health and allergy treatment markets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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