Thermo Fisher Scientific Phospho-FFA4 (Thr349, Ser350) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Target Information

An EST for GPR120 has been isolated from a human colon cancer library.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors.
Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs.
This "turn-off" activity has tremendous implications for the physiological action of the cell and continues to drive pharmacological research for new drug candidates.
Two blockbuster drugs developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which have multi-billion dollar shares of the mental health and allergy markets, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.