Thermo Fisher Scientific KEAP1 Polyclonal Antibody
Human KEAP1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 사용 가능. KLH 결합 합성 펩타이드(aa 422-449)를 면역원으로 제작. Protein A 및 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 422–449 amino acids from the C-terminal region of human KEAP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541101 |
Product Specific Information
This antibody is predicted to react with porcine based on sequence homology.
Target Information
The KEAP1 gene encodes a protein containing KELCH-1-like domains and a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 (Nrf2) in a redox-sensitive manner. Dissociation of these proteins in the cytoplasm leads to the transport of Nrf2 to the nucleus, inducing expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been identified for this gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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