Thermo Fisher Scientific Angiopoietin 2 Polyclonal Antibody
Thermo Fisher Scientific의 Angiopoietin 2 Polyclonal Antibody는 인간 및 생쥐 시료에 반응하며, WB, IHC, Flow Cytometry에 사용 가능. Rabbit IgG 폴리클로날 항체로 고순도 정제, 안정적 액상 형태. 연구용으로 혈관신생 관련 단백질 분석에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Flow Cytometry (Flow) | 1:25 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 404–432 amino acids from the C-terminal region of human ANGPT2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.0 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541112 |
Target Information
ANG-2 binds to the endothelial cell specific receptor Tie-2, but unlike ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis.
The signaling interactions of ANG-1, ANG-2, and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels.
Mature human ANG-2 is a secreted protein containing 480 amino acid residues, composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain, existing predominantly as a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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