Thermo Fisher Scientific MCF2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  VKMTWLKEIR NILLKQQELL TVKKRKQQDQ LTERDKFQIS LQQNDEKQQG AFISTEETEL EHTSTVVEVC EAIASVQAEA NTVWTEASQS AEISEEPAEW SSNYFYPTYD ENEEENRPLM RPVSEMALLY
• Positive Samples: HT-29
• Cellular Location: Cytoplasm, Membrane

Target Information

Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes conversion of Rho family GTPases from GDP-bound to GTP-bound form.

• Isoform 1: No activity toward RHOA, RAC1, CDC42
• Isoform 2: Decreased GEF activity toward CDC42
• Isoform 3: Weak but significant activity toward RAC1 and CDC42
• Isoform 4: Significant activity toward RHOA and CDC42
• Truncated DBL oncogene: Active toward RHOA, RAC1, CDC42

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.