Thermo Fisher Scientific Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitution:

• Reconstitute with 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
• Ships as a lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• After reconstitution, store at 4°C for up to 1 week.
• For long-term storage, make small aliquots and store at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome.
CHRFAM7A, a fusion protein comprised of FAM7A and AChR alpha7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 associated with several neuropsychiatric disorders such as schizophrenia and bipolar affective disorder.
CHRFAM7A (also known as D-10 or CHRNA7) is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, mediating signal transmission at synapses.
It is expressed in the hippocampus, and alternative splicing of the CHRFAM7A gene produces two splice variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.