Thermo Fisher Scientific ITGB1BP1 Monoclonal Antibody (OTI7A7), TrueMAB

Applications

• Western Blot (WB): Tested Dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ITGB1BP1 is a key regulator of integrin-mediated cell–matrix interaction signaling.
It binds to the ITGB1 cytoplasmic tail, preventing activation of integrin α5β1 by talin or FERMT1.
Functions include:

• Regulation of cell proliferation, differentiation, adhesion, and migration
• Modulation of focal adhesion dynamics and integrin clustering
• GDI activity regulating Rho family GTPases (CDC42, RAC1)
• Promotion of ROCK1 translocation and myoblast migration
• Role in osteoblast differentiation and bone mineralization
• Regulation of angiogenesis via Notch signaling and AKT/ERK pathways
• Enhancement of MYC promoter transcriptional activity

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.

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