Thermo Fisher Scientific IL-8 Polyclonal Antibody
IL-8 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 응용(WB, IHC, ELISA, IP)에 사용 가능하며, 인간 시료에 반응. 고농도(75 mg/mL) 액상 형태로 제공되며, -20°C에서 안정적으로 보관 가능.
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- 109-401-311x (3개 옵션)
- 판매단위
- pk
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3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-8 Polyclonal Antibody
Thermo Fisher Scientific IL-8 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:400–1:800 |
| ELISA | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 1:500–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Whole rabbit serum prepared by repeated immunizations with recombinant human IL-8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 75 mg/mL |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge if not completely clear after standing at room temperature. Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
The antiserum detects recombinant and native IL-8 present in body fluids and cell supernatants in ELISA. Although likely functional, this antiserum has not been evaluated in other assays, including neutralization and immunohistochemistry.
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72-amino-acid pro-inflammatory factor belonging to the CXC chemokine subfamily. It binds to IL-8RA and IL-8RB receptors and functions as a chemoattractant and potent angiogenic factor. IL-8 expression and secretion are induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
IL-8 contains the ELR-motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors. Previous names include NAP-1, GCP-1, MONAP, and protein 3-10C. IL-8 and related CXC chemokines form a gene cluster on chromosome 4q. Studies indicate IL-8 plays roles in tumor angiogenesis, growth, and bronchiolitis pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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