Thermo Fisher Scientific PTGER3 Polyclonal Antibody
Thermo Fisher Scientific의 PTGER3 Polyclonal Antibody는 Mouse 및 Rat 시료에 반응하는 Rabbit IgG 기반 항체로, Western blot과 ELISA에 적합합니다. 고순도 Affinity Chromatography로 정제되었으며, 안정적인 액상 형태로 제공되어 연구용으로 신뢰성 높은 결과를 제공합니다.
- 카탈로그번호
- PA592124
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–53 of human PGE receptor EP3 (PTGER3) (NP_9420091) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.06 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806385 |
Product Specific Information
- Immunogen sequence: MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV SVA
- Positive Samples: Mouse kidney, Rat kidney
- Cellular Location: Cell membrane, Multi-pass membrane protein
Target Information
CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells, macrophages, mast cells, and hematopoietic stem cells.
It acts as a substrate for activated tyrosine kinases (EGFR, PDGFR, src, insulin receptor) and negatively regulates receptor tyrosine kinase-coupled signaling pathways.
Binding of CD172a to CD47 triggers phosphorylation of ITIMs, recruiting tyrosine phosphatases SHP-1 and SHP-2, which regulate cellular functions through substrate dephosphorylation.
CD172a–CD47 ligation is involved in inhibition of macrophage phagocytosis and bidirectional activation of T cells and dendritic cells.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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