Thermo Fisher Scientific N4BP2L2 Polyclonal Antibody
N4BP2L2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며, 고순도(>95%)로 정제되었습니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 400–445 of human N4BP2L2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553866 |
Product Specific Information
- Detects endogenous N4BP2L2 protein at approximately 67 kDa.
- Purity: >95% by SDS-PAGE.
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation.
It is phosphorylated on Ser199 in response to DNA damage, likely by ATM or ATR.
Primarily expressed in bone marrow, N4BP2L2 is down-regulated after exposure to arsenic compounds, preceding neutropenia.
PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, both implicated in neutropenia disorders.
Defects in the ELA2 gene encoding Neutrophil Elastase cause cyclic haematopoiesis, leading to reduced neutrophil counts and increased infection risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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